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These guidelines synthesize evidence from multiple trials and provide recommendations on patient selection, dosing, monitoring, and combination therapy strategies

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For instance, as learned by X-ray crystallographic studies of complexes of the enzymes with glutathione alkyl thioethers as non-covalent inhibitors, in human α class glutathione transferase A1-1 the sulphur atom forms a hydrogen bond to the hydroxyl group of a tyrosine and to the guanido group of an arginine [130,131,132]