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It is a well-established model for osteoarthritis, especially in cohorts of older age than we used here (52w) (Botter et al., 2011) and for the unhealthy loss in muscle (sarcopenia) and fat mass(Wijnhoven et al., 2005)
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Researchers use these peptides together in complex tissue regeneration models, including studies of skin, tendon, muscle, gastrointestinal mucosa, and vascular tissue, to investigate how coordinated signaling can influence processes like inflammation resolution, collagen deposition, vascular integration, and cellular coordination
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