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Intracellular 1-MNA in cultured adipocytes plateaued near 40% of untreated control levels, and in mice 1-MNA in plasma, epididymal white adipose tissue and liver serves as the target-engagement biomarker
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1,2 Recent studies have investigated the genetic and molecular basis of primary lymphedema, and have identified several genes and signaling pathways involved in lymphatic development and function
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