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Independently of routes, most flavonoids exhibited free radical scavenger ability, particularly toward NO • [155], [170], [171], [172], reduced lipid peroxidation [83], [155], [170], [171], [172], promoted an increase in antioxidant defense, principally through SOD activity [83], [155], [170], [171], [172] and GSH levels [83], [155], [156], [171]

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However, it is known that MPT can participate in several other forms of cell death ( The onset of MPT is characterized by the permeabilization of the MOM secondary to a sudden increase in permeability of the MIM, which allows the exit of molecules less than 1500 Da ( Oxidative stress induces MPT by targeting specific cysteine residues of cyclophillin D, which results in mitochondrial depolarization, oxidative phosphorylation uncoupling, release of intra-mitochondrial ions and metabolic intermediates, mitochondrial swelling and decrease in ATP synthesis