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Consequently, GATA1 and GATA2 expression levels show dynamic features, referred to as “GATA-factor switching,” during erythroid differentiation ( GATA1 has four functional domains, consisting of two transactivation domains that reside in the amino (N)- and carboxyl (C)-termini and two zinc-finger domains that are referred to as N- and C-terminal zinc fingers in the middle of the protein