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The larger needle makes it easy to draw water but would be unnecessarily painful for subcutaneous injection

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In the NETs‐rich TME, CD8 + T lymphocytes exhibit a functionally exhausted phenotype and express high levels of exhaustion markers, such as PD‐1, lymphocyte activation gene‐3 (LAG‐3) or T cell immunoglobulin and mucin domain 3 (TIM3, an inhibitory checkpoint protein highly expressed in tumor‐infiltrating lymphocytes), and NETs inhibitors can reverse this phenotypic switch [132]