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The idea further proved that CAT induced UGT1A6, a phase II detoxifying enzyme of TP, through the Nrf2 pathway, thereby increasing TP metabolic conversion and reducing TP hepatotoxic effects ( As an upstream regulator, Nrf2 not only regulates the oxidative stress response but also suppresses inflammation by regulating cytokine production and cross-talk with the NF-κB signaling pathway (Keleku-Lukwete et al., 2018)

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