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in Table 2), and pharmacological, behavioral, and peripheral interventions that also affect the brain such as neurotransmitter modulators (e.g., duloxetine, bupropion), peripheral nerve stimulation (transcutaneous electrical nerve stimulation, scrambler therapy, vagus nerve stimulation), meditation, exercise, and cognitive behavioral therapy or combination therapies to amplify an intervention’s effect on the brain (e.g., tDCS during exercise, duloxetine plus exercise)

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7 Challenges and prospects The endotoxemia–TLR4 axis offers a pragmatic “mechanism-to-therapy” bridge by connecting a modifiable upstream driver (barrier-dependent portal LPS/PAMP exposure) (203)