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Moreover, higher iron content across cortical/subcortical gray matter and hippocampal subfields correlates with memory decrements even in cognitively normal older adults (Spence et al., 2022)

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Furthermore, by securing their metabolic resilience against ferroptosis, DJ-1-competent astrocytes can better provide trophic support, regulate extracellular glutamate, and mitigate neuroinflammatory cascades, all processes that indirectly influence neuronal susceptibility to ferroptotic death (Cao et al., 2020)