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In the Fenton reaction, free Fe(II) reacts with H 2 O 2 , producing Fe(III), hydroxyl radical ( • OH), and hydroxide ion (OH − ) [1]

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Examples include: 6-Nitro-2-trifluoromethyl-2H- 1 -benzopyran- 3-carboxylic acid 6-Chloro-8-methyl-2-trifluoromethyl-2H- 1 - benzopyran-3-carboxylic acid 2-Trifluoromethyl-2H-naphtho[2,3-b]pyran-3- carboxylic acid 6-Chloro-7-(4-nitrophenoxy)-2-(trifluoromethyl)- 2H- 1 -benzopyran-3 - carboxylic acid ((S)-6,8-Dichloro-2-(trifluoromethyl)-2H-l-benzopyran- 3 -carboxylic acid 2- (Trifluoromethyl)-6-[(trifluoro- methyl)thio]-2H-l-benzothiopyran- - carboxylic acid 6, 8 -Di chl oro-2-trifluoromethy 1 -2H- 1 -b enzothi opy ran- 3-carboxylic acid 6-(l , 1 -Dimethylethyl)-2-(trifluoromethyl)-2H- 1 - benzothiopyran-3-carboxylic acid 6-Chloro- 1 ,2-dihydro- 1 -methyl-2-(trifluoromethyl)-3 - quinolinecarboxylic acid 6-Chloro-2-(trifluoromethyl)- l,2-dihydro[l,8]naphthyridine- -carboxylic acid ((S)-6-Chloro-l,2-dihydro-2-(trifluoromethyl)-3- quinolinecarboxylic acid (2S)-8-ethyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H- chromene-3-carboxylic acid (2S)-6-chloro-5,7-dimethyl-2- (trifluoromethyl)-2H-chromene-3 - carboxylic acid [00194] In preferred embodiments the chromene Cox-2 inhibitor is selected from (S)- 6-chloro-7-(l, l-dimethylethyl)-2-(trifluoromethyl)-2H-l-benzopyran-3 -carboxylic acid, (2S)- 6,8-dimethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, (2S)-6-chloro-8-methyl-2- (trifluoromethyl)-2H-chromene-3-carboxylic acid, (2S)-8-ethyl-6-(trifluoromethoxy)-2- (trifluoromethyl)-2H-chromene-3-carboxylic acid, (S)-6,8-dichloro-2-(trifluoromethyl)-2H-l- benzopyran-3 -carboxylic acid, (2S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chromene- 3 -carboxylic acid, and mixtures thereof