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Injectable vs Topical: What the Route Actually Changes The route difference here is not a detail — it is the difference between the evidence base that exists and the one that doesn’t

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Importantly, high-dose regimens—particularly bolus or intermittent administration—have not demonstrated clear clinical benefits in randomized controlled trials [271, 272].On the contrary, several studies have suggested that such strategies may increase the risk of adverse outcomes, including falls [273, 274]