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In Plasmodium falciparum , a copper efflux P-ATPase has been identified and partly characterized (Rasoloson et al., 2004), as was a copper-binding protein with sequence features characteristic of copper transporters, including three transmembrane domains: an extracellular copper-binding methionine motif and transmembrane Gx 3 G and Mx 3 M motifs (Choveaux et al., 2012)