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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)
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Currently, a long term clinical trial is investigating the effects of semaglutide on the development and progression of DR and is planned to conclude in 2027 (ClinicalTrials.gov number, NCT03811561)
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