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It was also observed that HPV-16 E7 binding does not impose any apparent steric hindrance on the residues forming the active site of the enzyme, the glutathione binding site (G-site, occupied by a glutathione molecule in Figure 3A), or the substrate binding site (H-site, occupied by chlorambucil in Figure 3A)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Vergura R., Balboni G., Spagnolo B., Gavioli E., Lambert D.G., McDonald J., Trapella C., Lazarus L.H., Regoli D., Guerrini R., Salvadori S., Calo G