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ER stress in type 1 and type 2 diabetes: a comparative overview Extensive research over the past 15 years has consistently shown that ER stress plays a pivotal role in the dysfunction and failure of pancreatic β-cells in both type 1 diabetes mellitus (T1DM) and T2DM
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Hormone therapy acquired resistance occurs after the suppression of ER function with selective estrogen receptor modulators (SERMs) such as tamoxifen 75 or by lowering serum estradiol (E2) levels or blocking peripheral conversion of adrenal precursors with aromatase inhibitors
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