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The evolution of obesity medicines captured in a single image. Semaglutide activates a single pathway (GLP-1). Tirzepatide engages two (GLP-1 + GIP). Retatrutide goes further with three — adding glucagon, which directly

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Moreover, the extended activation of the mTORC1 pathway in the vascular system due to BCAAs may also explain the association between these amino acids and BP, as it can lead to several physiological alterations, including changes in sympathetic nerve activity [62], proliferation of vascular smooth muscle cells [63], and kidney damage [64], which can subsequently contribute to the onset of hypertension [59]