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Although dopamine agonists have been shown to be initially effective, long-term use can cause symptoms to worsen again, such as making the symptoms to start earlier in the day, becoming stronger, or spreading to other body parts, and because of this risk and other side effects, current guidelines place more emphasis on α2δ ligands and careful evaluation and correction of iron deficiency (Supplementary File 1

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CoA is also used to ‘activate’ free fatty acids, prior to incorporation into membrane phospholipids by acyl-CoA synthetase long chain family member (ACSL) enzymes [39–42]