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By increasing the expression of mitochondrial iron-related regulators such as SLC25A28 and FDXR, p53 may further expand the pool of redox-active labile iron and thereby amplify ferroptotic signaling (Wang et al., 2023

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Glutathionylation is also known to occur via direct oxidation of a target protein as represented below: The GST-protein family members are known to post-translationally modify several target proteins by catalyzing the forward S-glutathionylation reaction [9]