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Indeed, the interconversion of serine and glycine via the involvement of THF represents the major pathway for the generation of N 5 , N 10 -methylene-THF which of a member of the active pool of folate derivatives
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227 In pathological iron overload, this DMT1 iron transport process is aggravated by increased TFR1 saturation, leading to the generation of toxic NTBI, which then causes β cell damage through ferroptosis
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