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Thermostable DNA polymerases represent a classic and transformative example of extremozymes, such as Taq polymerase from Thermus aquaticus , Pfu polymerase from Pyrococcus furiosus , and KOD polymerase from Thermococcus kodakarensis , retains high catalytic activity at elevated temperatures and enables efficient PCR amplification, outperforming mesophilic polymerases that denature during thermal cycling (Cline et al., 1996
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