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Another enzyme, Cytochrome P-450 1B1 (CYP1B1), is involved in the conversion of 17beta-estradiol to 4-hydroxyestradiol, a mutagenic metabolite implicated in breast and endometrial carcinogenesis
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Clinical outcomes in patients are presenting with a systemic oxidative burden, which results in persistent fatigue, delayed recovery from physical exertion, and early dermatological signs of premature aging
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