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9% use it for 45+ days[¹⁶] These “safe” therapeutic doses can significantly deplete glutathione in women who already have low baseline levels.[²¹⁻²³] Healthy individuals can tolerate up to 4g/day with only modest glutathione decrease, but individuals with compromised glutathione experience significant depletion even at therapeutic doses

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A visual comparison of the main study types used in GHK-Cu research