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Significant changes in leptin, which is regarded as a special body weight regulating hormone, were also noted (29), meaning that the resistance to leptin is partly improved in obese subjects
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To unravel the tripartite interplay delineated microbial‐epithelial‐immune crosstalk, we adopted a multi‐omics approach combining 16S rRNA sequencing, targeted metabolomics, and transcriptomic profiling of IECs
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