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Pattern recognition receptor (PRR)-dependent pathway: cholesterol-rich microdomains exposed on the crystal surface directly bind to Toll-like receptors 2/4 (TLR2/4), thereby initiating the MyD88 signaling cascade (Bhadouria et al., 2025
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Additionally, systemic side effects associated with sustained growth hormone stimulation include symptoms such as abnormal tissue growth, joint discomfort, and potential enlargement of the heart (cardiomegaly), Roberts says (21)
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