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399,400 TAMs originate both from circulating monocytes recruited by tumor-derived chemokines such as CCL2 and CSF-1 and from tissue-resident macrophages that are re-educated by tumor-derived signals
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Specifically, activated AhR translocates to the nucleus and binds to specific DNA sequences, leading to the upregulation of genes encoding pro-inflammatory cytokines such as TNF-α and IL-6, as well as chemokines like C-X-C motif chemokine ligand (CXCL)8
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