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It should be then underscored that 5-HT is not only a brain neurotransmitter but also one of the main initiators of the inflammatory response in the body, acting as a vasoactive player, released by platelets and leukocytes, along with other biogenic amines such as histamine, peptides, eicosanoids, proinflammatory cytokines, and acute phase proteins (113, 114): essentially, 5-HT holds the ability to modulate both behavioral and inflammatory defense responses related to depression (114, 115)

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Its calming effect can relax both the muscles and the nervous system helping to reduce the restless sensations and legging often associated with RLS