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in effect, the sensory filter ‘disintegrates’ : “Based on this literature and observations from our own laboratory and others on the role of astroglial cells in the fine-tuning of glutamate neurotransmission we present the hypothesis that the proinflammatory cytokines tumor necrosis factor- α , IL-1 β and IL-6 could be involved in the pathophysiology of mental fatigue through their ability to attenuate the astroglial clearance of extracellular glutamate, their disintegration of the blood brain barrier, and effects on astroglial metabolism and metabolic supply for the neurons, thereby attenuating glutamate transmission

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doi: 10.3389/fimmu.2026.1722134 Received 20 October 2025 Revised 10 February 2026 Accepted 10 February 2026 Published 25 March 2026 Volume 17 - 2026 Edited by Georgia Damoraki, National and Kapodistrian University of Athens, Greece Reviewed by Naheed Aryaeian, Iran University of Medical Sciences, Iran Updates Copyright © 2026 Cai