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In cancer, heart diseases, or chronic obstructive pulmonary disorders, the cellular oxygen balance is highly impaired, and cells become hypoxic (having low oxygen (O 2 ) levels) 1
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More recent mechanistic studies suggest that TXNIP may play a causal role in β-cell damage and death in response to hyperglycemia, as TXNIP overexpression causes β-cell apoptosis, and TXNIP deficiency promotes β-cell survival (60–62)
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