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Only PLD2-activating and MOR-internalizing agonists such as DAMGO, β -endorphin, methadone, piritramide, fentanyl, sufentanil, or etonitazene were found to stimulate the MOR-mediated production of reactive oxygen molecules, primarily H 2 O 2 , via NADH/NADPH oxidase (Koch et al., 2009)
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He's technically still "in range" at all three ages, but he's lost 40% of his testosterone over four decades
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