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This increase in extracellular 5-HT in the intestinal mucosa activates the 5-HT receptors (such as 5-HT3) of myenteric neurons, smooth muscle cells, and epithelial cells, which causes increased intestinal secretion and motility to aid in pathogen clearance [272, 276, 277]

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Study Highlights WHAT IS KNOWN ✓ In the phase 3 QUASAR maintenance study in participants with ulcerative colitis, guselkumab-treated participants achieved the primary endpoint of clinical remission at maintenance week 44 and all major secondary endpoints, including achievement of endoscopic improvement, endoscopic remission, and histo-endoscopic mucosal improvement at maintenance week 44, compared with placebo

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