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This shift leads to succinate accumulation in the TCA cycle, which in turn stabilizes HIF-1α in a positive feedback loop, enhances inflammasome activity, and promotes macrophage pyroptosis (Li J
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doi: 10.1016/j.biotechadv.2013.06.007, 78 NapoleoniM.KlennerF.KhawajaN.HillierJ
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