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d , The mRNA of indicated inflammatory genes was determined by reverse transcription and real-time PCR using the liver of wildtype (n = 4 for mock, n = 6 for HSV-1 infection), NAMPT-KO (n = 4 for mock, n = 5 for HSV-1 infection) and NAMPT-KO mice with nicotinamide riboside (dose: 400 mg/kg/day, n = 4 for mock, n = 5 for HSV-1 infection) at 3 days post-infection of HSV-1 (2 × 10 7 PFU, intravenous)

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Mechanistically, it follows the same biochemical pathway as other caloric restriction mimics: it induces protein deacetylation and relies on autophagy [66]