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Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver
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In a targeted DNA methylation study focusing on five genes involved in fibrogenesis modulation, the results showed hypomethylation of pro-fibrogenic genes (TGFβ1 and PDGFα) and hypermethylation of anti-fibrogenic genes (PPARα and PPARδ) in advanced MASLD compared to mild cases, suggesting that the methylation status of specific CpGs could potentially predict the severity and progression of MASLD to liver fibrosis [340]
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