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Furthermore, the resulting chlorinative stress may lead to multiorgan damage in COVID-19 through various mechanisms, including oxygen competition for heme-binding sites, decreased oxygen saturation, hemoglobin-heme iron oxidation, heme degradation, and iron release [88]
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349,350 The ongoing phase 3 study ELAINE-3 (NCT05696626) aims to evaluate the effects of abemaciclib combined with either lasofoxifene or fulvestrant in patients with ESR1-mutated, locally advanced or metastatic ER+/HER2− breast cancer
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