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Folic acid deficiency The overall mean of serum folate concentration was 12.5 ng/mL (95%CI 12.1,12.9) and the overall prevalence of folate deficiency was 3.2% (Table I)
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In the pooled safety analysis of four placebo-controlled trials, 1,997 patients who received at least one dose, neck pain was reported by 12.6%, muscle weakness by 8.0%, stiffness by 6.1%, and ptosis by 4.6%, with 3.4% discontinuing because of a side effect (Diener 2014)
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