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Firstly, In the pathological state of RA, fibroblast-like synoviocyte (FLS) shows abnormal biological behavior similar to tumor cells, including strong invasiveness and migration ability, excessive proliferation and anti-apoptosis, resulting in active metabolism and decreased blood flow in synovial tissue, resulting in a large increase in oxygen consumption and aggravation of local tissue hypoxia, thus forming an hypoxic microenvironment (6)
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Trends Parasitol (2019) 35(2):104–8
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