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1 Introduction According to the World Health Organization, more than 55 million people currently live with dementia, and this number is expected to reach 139 million by the year 2050 ( Recent developments in research on the microbiota-gut-brain axis (MGBA) open new opportunities to develop microbiome-based interventions with benefits for NDD symptoms and pathophysiology ( This narrative review provides an overview of the current understanding of the role of the MGBA in the onset and progression of NDDs and summarizes evidence on microbiome-based interventions that could prevent or delay their course and help manage core clinical symptoms