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Hepato-protectant (NAC) and ER stress inhibitor (4-PBA) significantly downregulated ER stress markers in the liver compared to the MTX group, as depicted in Figures 6A–E
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An important next step will be to establish robust biomarkers—molecular, lipidomic and functional—that predict response to CoQ 10 -axis perturbation alone or in combination with standard therapies
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