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Frontiers | The gut–brain axis: mechanisms linking intestinal dysbiosis with stroke

In a preclinical study conducted on MC38 colon tumor-bearing mice, the combination of avasimibe and an anti-PD-1 antibody displayed superior efficacy in controlling tumor progression compared to either monotherapy, resulting in a significant anti-tumor effect [172]

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A trend toward 11% reduced complex IV activity was seen in dld‑1(RNAi) worms compared with N2, which reached only marginal statistical significance ( P = 0.06) (Figure 5B)