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Variances in circadian phase, light responsiveness, and clock gene expression identified between older and younger adults [41], could lead to a different reaction to vitamin B12

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Accordingly, increased GSTP1 expression is often detected in many cancers (e.g., breast, colon, stomach, pancreas, bladder, lung, head and neck, ovary and cervix, soft tissue sarcoma, testicular embryonic carcinoma, meningioma, and glioma), which is associated to enhanced detoxification activity, thus protecting cancer cells against cytotoxic and cytostatic drugs (Ruzza et al., 2009)