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That decline lines up with the years when skin loses firmness and wounds heal slower, which is a big reason researchers got interested in putting it back

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DILI is a leading cause of drug failures in clinical trials, black box warnings, and withdrawals for marketed drugs, but precise mechanisms are difficult to establish because it can involve the parent drug, its metabolites, and the immune system of the host, and also because it may be intrinsic or idiosyncratic (Allison et al., 2023

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