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4.1 The impact of HDAC inhibitors on neuronal loss and glial activation The common HDAC inhibitors can be divided into four groups based on their structure: butyric acid derivatives (e.g., valproic acid), hydroxamic acid derivatives (e.g., suberoylanilide hydroxamic acid), benzamides (e.g., entestat) and cyclic tetrapeptides (e.g., romidepsin) (Bezu et al., 2019)

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CRS occurs in up to two thirds of patients, is usually low-grade, and is primarily observed during step-up dosing and the first full dose, while ICANS is rare and may occur in association with CRS

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