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The thyroid gland impacts: The Immune System Although the immune system may the source of the problem in an autoimmune condition, there is a vicious cycle whereby thyroid dysfunction creates further immune dysregulation through a variety of mechanisms including: Increase intestinal, lung and blood brain barrier permeability due to increased inflammatory load and poor regeneration potential T cell dysregulation Dendritic cell dysregulation Macrophage dysregulation Decreased antioxidant production and oxidation stress Systemic inflammation, neuroinflammation The Brain Two of the most common symptoms of underactive thyroid are fatigue and depression which could be due to brain derived mechanisms

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First, depth of peer-reviewed research: how much real clinical or preclinical data exists