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“Bookrunning tends to be fairly closely held, so being able to build some of that experience for people at those firms that they can take and use to generate more business is something that I think is really valuable,” Wells Fargo Treasurer Neal Blinde told American Banker
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Specifically, the upregulation of the Nrf2 pathway triggers the production of phase II detoxifying/antioxidant enzymes, such as HO-1 and GSTa, while the downregulation of the TLR2/MyD88/NF-κB pathway results in a decreased production of pro-inflammatory cytokines, including IL-1β, IL-8, and TNF-α
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