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Figure 1 2.1 The core enzymatic triad: BCAT4, MAM1, and CYP79F1 The commitment of methionine to aliphatic glucosinolate synthesis is driven by three pivotal enzymes, each executing a distinct and non-redundant step in the construction of the glucoraphanin backbone ( Figure 2 )

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Importantly, metformin exerts an acute glucose-lowering effect in liver-specific [201] and intestine-specific [202] AMPK knockout mouse models, indicating the presence of AMPK-independent mechanisms (reviewed in Ref