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doi: 10.1371/journal.pone.0120228

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In recent years, the potential of natural compounds in the treatment of neurodevelopmental disorders has gradually gained attention, among which the pine bark polyphenol extract, a natural compound extracted from the bark of the French coastal pine tree, which main component is proanthocyanidins, has become a hot research topic due to its antioxidant, anti-inflammatory and neuroprotective effects (Schoonees et al., 2012)