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The anti-inflammatory properties of MSM are thought to be due to its ability to inhibit the release of pro-inflammatory cytokines and prostaglandins
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However, pro-inflammatory stimuli disrupt mitochondrial TCA cycling, causing the accumulation of citrate, which is exported to the cytoplasm for acetyl-CoA conversion, driving de novo lipogenesis (DNL) and LD biogenesis (94,95)
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