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Other studies were published in the context of the “EMC Trial - (early medication change trial)”, which was aimed at investigating whether non-improver after 14 days of the antidepressant escitalopram were more likely to remitafter 8 weeks of treatment with an early medication change, compared to patients treated according to current guideline recommendations (ClinicalTrials.gov identifier n◦: NCT00974155 [50])

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Given the convenience, low cost, and widespread availability of advanced transgenic animals, the majority of TBI research is performed in rodent models of controlled cortical impact, lateral fluid percussion, or weight drop-induced injury