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Drug interactions In theory, because lipoic acid supplementation may improve insulin-mediated glucose utilization (see Diabetes mellitus), there is a potential risk of hypoglycemia in diabetic patients using insulin or oral anti-diabetic agents (118)

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Clinical features include: Enlargement of the hands, feet, and jaw Paraesthesia in the extremities Amenorrhoea Coarse facial features, including a wide nose and rounded face Hypertension Cardiomegaly (enlargement of the heart) Treatment includes surgical removal of the pituitary tumour , typically via the sphenoid bone (“transsphenoidal” approach) if the tumour is large enough, or medical management using somatostatin analogues.