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NO activates soluble GC (sGC) by binding to the ferrous (Fe 2+ ) heme, forming a 5‐coordinate high‐spin ferrous nitrosyl complex, representing the active form of the enzyme
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Notably, the function of palmitoylation varies significantly across different cancer types, acting as either a carcinogenic driver or a tumor suppressor, making it a therapeutic target fraught with both challenges and opportunities (Figure 2)
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